Pharmacokinetics of sufentanil

Aspects of pharmacokinetics and pharmacodynamics of sufentanil in pediatric practice.

Sufentanil is a potent synthetic opioid. Like other opioids, sufentanil creates a stable hemodynamic environment in cardiovascularly compromised pediatric patients. Clearance, expressed as per kilogram, is increased in children compared to adults. The P450 CYP3A4 enzyme is responsible for the major metabolic N-dealkylation pathway. Enzyme activity is reduced in neonates but the maturation of su...

The pharmacokinetics of fentanyl, sufentanil and alfentanil: a comparative review.

Pharmacokinetics and effects on intracranial pressure of sufentanil in head trauma patients.

Ten patients with head trauma received an intravenous bolus of sufentanil (2 micrograms kg-1) followed at 30 min by infusion of sufentanil (median 150 micrograms h-1) and midazolam (median 9.0 mg h-1) over 48 h. Median (range) values of pharmacokinetic parameters for sufentanil were: t1/2,z = 16 (7-49) h; CL = 1215 (519-2550) ml min-1; CLR = 7 (2-38) ml min-1; Vss = 10.0 (6.8-24.2) 1 kg-1. Decr...

Sufentanil Citrate Injection, USP CII

At intravenous dosages of ≥8 mcg/kg, sufentanil produces hypnosis and anesthesia without the use of additional anesthetic agents. A deep level of anesthesia is maintained at these dosages, as demonstrated by EEG patterns. Dosages of up to 25 mcg/kg attenuate the sympathetic response to surgical stress. The catecholamine response, particularly norepinephrine, is further attenuated at doses of su...

Electroencephalographic effects of sufentanil anaesthesia in man.

The effects of anaesthesia with sufentanil 15 micrograms kg-1, air and oxygen on the electroencephalograph were studied in 12 patients before and after cardiopulmonary bypass. The e.e.g. responses were characterized by high voltage, slow delta waves. Although the mean power in the delta band declined with time, the contribution of delta power to total power in the frequency range 0.5-40 Hz rema...